As an artist Frederik De Wilde acts on the border area between science, technology and art. It is this interstitial territory that Frederik De Wilde explores in his various works. Sometimes on the side of the technological, and often in the perceptual, conceptual, social–human–register, De Wilde's art is grounded in the interaction between complex systems, both biological and technological. Moreover, the indistinct, diffuse, 'fuzzy' arena where the biological and the technological overlap and commingle is a productive and favored ground for his projects/projections. 

The conceptual crux of his artistic praxis are the notions of the intangible, inaudible, invisible and moreover, the dematerialization of the artwork. In order to pursue this concept Frederik works, for instance, with nanotechnology, biotechnology, information and data networks, environmental data, et al. In 2010 he created Hostage, the darkest nano engineered painting in the world, in collaboration with Rice University (Texas, Houston, USA).