As of young age he started playing music and later enrolled, he first studied classical music at the Mechelen Conservatory, and thereafter at the Royal Antwerp Conservatory.

Since 1983, he leads a variety of groups. He works for a while as a freelance saxophonist in the BRTN (radio & television) Jazz Orchestra and in '87 was responsible for a show with Toots Thielemans. He was also a member of the Timeless Orchestra, a big band with which he toured Europe and Japan.

His first album 'Picture of a view' was released in 1991. This was the period during which he was part of a quartet named 'Del Ferro-Vaganée group', with Dutch pianist Mike Del Ferro. In 1993, they recorded "Introducing" And later on "Del Ferro-Vaganée group live". During a 4 years period the quartet played a total of 125 concerts.

Frank Vaganée was also member of a trio with Philippe Aerts (double bass) and Dré Pallemaerts (drums). They performed at the 'European jazzfesitval' in Rabat (Morocco).

Frank is the leader and one of the contributing composers of the outstanding Brussels Jazz Orchestra, a big band of 16 musicians. He was, in 1993, one of the founders. Since then, the band goes from fame to fame, collecting awards and praise and collaborations.

In 1997, he performed, as soloist, in Japan during a series of 10 concerts in collaboration with 'Ebina Rhythm Research Institute'. End March 1998, Frank stayed for 3 months in New York to further improve his musical talent and also played at the 'Texaco Jazz festival' in New York.

In 1998, a new group is born with saxophonist John Ruocco, Italian bassist Rosario Bonaccorso and drummer Dré Pallemaerts. They recorded the CD Frank Vaganée Trio feat. John Ruocco: Trios.

From 1987 to 1991, he taught at the Jazz Studio in Antwerp and from 1992 to 1994 at the Sweelinck Conservatory in Amsterdam (Holland). Currently (since 1993), he teaches at the Ghent Conservatory and at the Lemmensinstituut in Leuven