Stephane Ginsburgh has been praised for his daring piano playing whose "performance exhibits a sublime, unified beauty, like that found in the random latticework of a snowflake". He appears regularly in recitals and chamber music worldwide. He has performed at numerous festivals such as Ars Musica, Quincena Musical de San Sebastián, ZKM Imatronic, Agora at IRCAM, Bach Academie Brugge, Ultima Oslo, Darmstadt Ferienkurse, Gaida (Vilnius), Warsaw Autumn, Musica Strasbourg, Klara Festival and Accademia Chigiana.

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A tireless surveyor of the repertoire but also exploring new combinations including voice, percussion, performance or electronics, he dedicates much of his energy to contemporary music. He regularly plays with the Ictus Ensemble, has collaborated with many composers such as Frederic Rzewski, Jean-Luc Fafchamps, Stefan Prins, Alec Hall and Matthew Shlomowitz of whom he premiered works, as well as with choreographers such as Anne Teresa De Keersmaeker and visual artists. He appeared with violist Garth Knox, soprano Sarah Defrise, basse Shadi Torbey, percussionist Miquel Bernat and flutist Manuel Zurria. Stephane Ginsburgh loves immersive performances: he as played Prokofiev's complete piano sonatas, Galina Ustvolskaya's piano sonatas or Beethoven's six last sonatas in one evening.

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Ginsburgh recorded Feldman, Duchamp, Satie, Fafchamps for Sub Rosa. He recorded the world premiere of two pieces by David Toub for World Edition. His Prokofiev complete piano sonatas were released on Cypres Records in 2015. In 2018, Grand Piano/NAXOS published his recording of the world premiere of the "Bad-Tempered Electronic Keyboard", a series of 24 Preludes and Fugues by the composer and writer Anthony Burgess. In 2019, Kairos released "Piano Hero" which is included in an album dedicated to the music of Stefan Prins. His latest recordings for Sub Rosa feature Julius Eastman's complete music for four pianos and pieces for speaking pianist by Frederic Rzewski.​

He is a laureate of the Tenuto competition 1995 and has received the Pelemans Prize in 1999 from the Belgian composers union for his dedication in performing Belgian contemporary music. In 1998, Stephane Ginsburgh co-founded Sonar (previously le Bureau des Arts), a group of artists dedicated to different types of artistic expression and creation including music, dance and literature, which he directed until 2018. He has also been artistic director of the Centre Henri Pousseur, an electronic music studio in Liège, from 2010 until 2013.

Ginsburgh is a professor of piano at the Haute école de musique de Genève. He has given courses, talks and masterclasses at universities and conservatories in Brussels, Mons, Liège, Tel-Aviv, Luxembourg, Paris and London. After completing his studies with a master in music, he worked with Paul Badura-Skoda, Claude Helffer, Jerome Lowenthal and Vitaly Margulis.​ Stephane Ginsburgh holds a BA in philosophy of science from the Free University of Brussels (U.L.B.) and a DMA (PhD in the Arts) from the Vrije Universiteit Brussel en Koninklijk Conservatorium Brussel.

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