As a recital soloist, concerto soloist, chamber and orchestral musician, clarinetist Marco Mazzini has performed internationally in such prestigious places as Carnegie Hall (New York), Tama Center (Tokyo), Paleis voor Schone Kunsten (Brussels), Bijloke Concert Hall (Belgium), Gasteig Cultural Center (Germany) and the Paris Conservatory (Paris).

Marco Mazzini made his debut s a soloist with the Lima Philharmonic Orchestra,  as a winner of the  "Concurso Nacional de Conciertos" in Peru, under the baton of Miguel Harth-Bedoya.

He has participated in many music festivals such as the International Clarinet Festivals (Arizona, Oklahoma, Utah), November Music Festival (Belgium, Netherlands), Festival internacional de Música Contemporánea (Lima), New Art Festival (Ohio), Ostrava Days (Czech Republic). In 2005, he represented Peru for the first time in the World Clarinet Festival in Tokyo.

In Europe, he has collaborated with composers, musicians and ensembles such as Frederic Rzewski (USA), Dirk Brossé (Belgium), Martin Smolka (Czech Republic), Lubica Salamon-Cekovská (Slovakia), SEM Ensemble (New York), Vlaams Radio Orkest, Spiegel String Quartet (Belgium), Yuri Serov (Russia), Carlos Tarcha (Brazil), Viviane Spanoghe (Belgium) and the Ciurlionis String Quartet (Lithuania).

Marco Mazzini is particularly interested in supporting the performance of contemporary music. As a founding member of Thelema Trio, he plays a variety of chamber works written for not only the traditional clarinet, but also bass clarinet and contrabass clarinet. As principal clarinetist of the Ostrava International Orchestra (Czech Republic), he performs works by composers such a Stockhausen, Xenakis, Ligeti, Nono and Cage.

In 2006 Marco Mazzini founded Duo Dicto - a clarinet - piano duet - where he gets the opportunity to perform the most contrasting pieces by living Latin American composers, from tonal pieces for clarinet and piano, to solo works for contrabass clarinet and electronics.

Recent musical project includes his new  Kinsa Trio,  a young ensemble dedicated to perform  music written in Peru in the early XX century, and the  Gent Clarinet Quartet.

Since 2005 he is a BG France and Gonzalez reeds artist.

In December 2009 Marco Antonio Mazzini returns to Peru, his native country.